Previous studies have shown that the mRNA expression of Yes-associated protein (YAP) target genes (CCNE1, CTGF, Cyr61) was increased in pediatric HCC, demonstrating an enrichment of YAP nuclear localization and its activity in moderately differentiated pediatric HCC (LaQuaglia et al., 2016). This evidence concerns the gene CCNE1 and hepatocellular carcinoma.