Nevertheless, the top 10 upregulated loci identified by transcriptome approach from BA samples, including CSRNP1, IL6R, CPB2, TTR, TD O 2, SERPINC1, C6, DHTKD1, IGFBP1, and RDH16, might deepen our understanding of the transcriptional and post-transcriptional mechanisms among BA patients (Xiao et al., 2014). The gene discussed is RDH16; the disease is breast angiosarcoma.