Previous studies have shown that the mRNA expression of Yes-associated protein (YAP) target genes (CCNE1, CTGF, Cyr61) was increased in pediatric HCC, demonstrating an enrichment of YAP nuclear localization and its activity in moderately differentiated pediatric HCC (LaQuaglia et al., 2016). The gene discussed is CCN1; the disease is hepatocellular carcinoma.