Several genetic variants, including genes encoding transmembrane 6 superfamily member 2 (TM6SF2), patatin-like phospholipase domain-containing 3 (PNPLA3), glucokinase regulator (GCKR), and membrane bound O-acyl transferase 7 (MBOAT7), contribute to the risk of NAFLD, whereas protein phosphatase 1 regulatory subunit 3B (PPP1R3B) has been documented to have a protective effect against NAFLD (Valenti et al., 2010; Santoro et al., 2012; Kozlitina et al., 2014; Mancina et al., 2016; Dongiovanni et al., 2018; Li et al., 2020). Here, PPP1R3B is linked to metabolic dysfunction-associated steatotic liver disease.