The reconstructed network demonstrates that TAp73/DNp73-dependent pathways (Alla et al., 2010, 2012) intercept with cellular receptor-triggered signaling cascades that are relevant for melanoma progression, such as EGFR (Sun et al., 2014; Wang et al., 2015), IGFR (Rosenbluth et al., 2008), and HER3 (Iorio et al., 2009; Tiwary et al., 2014) and portray the potential of p73 isoforms to sense changes in the cell microenvironment and modify the gene regulation programs accordingly (Figure 1C). The gene discussed is TP73; the disease is melanoma.