TP73 and cancer: Increased cancer stemness, together with the loss of original cell identity (de-differentiation), and the acquisition of characteristics of neuronal cell types upon p73 isoform expression, are overall indicative for their ability to switch from a melanocyte to a neuronal-like cell phenotype which would be theoretically able to foster a newly-emerged dangerous liaison between melanomas and the nervous system (Su et al., 2014; Lu et al., 2017; Logotheti et al., 2020b; Pomeranz Krummel et al., 2021).