The complete lack of overlap implies a ‘deterministic trend’ of DNp73 to develop highly “selective” PPIs with the candidate co-regulators; (Belyi and Levine, 2009) candidate p73 co-regulators are important neurodifferentiation/neurodevelopment factors, which suggests the involvement of neurodifferentiation programs in the effect of DNp73 on cancer aggressiveness; and (Belyi et al., 2010) the likely co-regulators for downregulated genes have different structures than those for upregulated genes: LHX6, PAX4, and LBX1 are homeobox proteins, whereas TFAP2B is a basic helix-loop-helix protein. Here, TP73 is linked to cancer.