It further sheds light on the mechanistical patterns governing its disparate functions by using the melanoma setting as a paradigm and suggests that a sophisticated and highly coordinated interplay between the p73 C-terminus, the protein interactome, target gene promoter architecture (Rudge et al., 2016) and the subcellular localization of TP73-derived isoforms can support this multifunctionality. This evidence concerns the gene TP73 and melanoma.