In gastric cancer, decreased S100A16 expression is involved in miR-6884-5p and ADAMTS19 (A Disintegrin and Metalloproteinase with Thrombospondin motifs 19) inhibition of GC cells migration, invasion, and EMT (Lv et al., 2020; Jiang et al., 2021), however, the role of S100A16 itself in GC metastasis has not been fully clarified yet. This evidence concerns the gene ADAMTS19 and gastric cancer.