TJP2 and carcinoma: Based on recent research, the interaction of ZO-2 with viral oncoproteins and kinases and its silencing in diverse carcinomas reinforce the view of ZO-2 as a tumor regulator protein (Yang et al., 2018; Akizuki et al., 2019; Gonzalez-Mariscal et al., 2019; Cong et al., 2020).