The molecular mechanisms of S100A16 involving in the tumor metastasis are diverse in various malignant tumors, including pancreatic cancer (Fang et al., 2021; Zhuang et al., 2021), leukemia (Zhang et al., 2019), breast cancer (Zhou et al., 2014), and so on. This evidence concerns the gene S100A16 and familial pancreatic carcinoma.