According to previous studies, S100A16 is upregulated in bladder cancer, lung cancer, pancreatic cancer, colorectal cancer and ovary cancer (Zhou et al., 2014; Bai et al., 2018; Sun et al., 2018; Fang et al., 2021; Zhuang et al., 2021), but the role of S100A16 in GC has not been fully elucidated before. This evidence concerns the gene S100A16 and colorectal cancer.