Increased levels of RANKL in menopausal women play a major role in the occurrence of osteoporosis, since the molecule can activate cell differentiation by binding to its receptor (RANK) and improves the activity and survival rate of osteoclasts (Eghbali-Fatourechi et al., 2003; Lacey et al., 2012). Here, TNFSF11 is linked to osteoporosis.