IGF1 and type 2 diabetes mellitus: IGF-1 is used as a marker of medical conditions and diseases, such as acromegaly, breast cancer (Peyrat et al., 1993; Hankinson et al., 1998; Tanimoto et al., 2008; Murphy et al., 2020), prostate cancer (Stattin et al., 2004; Rowlands et al., 2009), type 1 and type 2 diabetes (T2DM) (Mastrandrea et al., 2008; Cubbon et al., 2016), heart disease (Laughlin et al., 2004), non-alcoholic fatty liver disease (NAFLD) (Brea et al., 2005) and sepsis (de Groof et al., 2002).