AKT1 and sarcopenia: A supramolecular nanofiber/hydrogel formed by Nap-FFGSSSR mimics IGF-1 and can increase the phosphorylation of Akt by activating the insulin-mediated signaling pathway, which effectively promotes the proliferation of myoblasts, significantly reduces the apoptosis of myoblasts induced by dexamethasone, helps the myoblasts to differentiate into myotubes, and prevents the fibrosis of muscle tissue and the deposition of collagen;(Shang et al., 2020) these results show a prominent effect of IGF-1 in the treatment of sarcopenia.