IPO7 and cervical squamous intraepithelial neoplasia: Furthermore, the immunohistochemistry staining assay in a tissue microarray (TMA) validated that IPO7 was primarily located in the nucleus of CC tissues and that the protein level of IPO7 was significantly higher in CC tissues than in the normal cervix and CIN (cervical intraepithelial neoplasia) tissues (Figure 1F).