ZEB1 and central nervous system cancer: TIME cluster A exhibited the high expression profiles of ZEB1, TNF, and LAG3; while GZMA, CXCL9, CXCL10, and CD8A were relatively overexpressed in TIME cluster C. EMT is a common process of paramount importance in glioma occurrence and invasion (Du et al., 2017; Brabletz et al., 2018).