Previous research demonstrated that M2 macrophages could secrete several immune suppressors such as IL-10 and TGF-β and could downregulate IL-12 and IL-6, contributing to the suppression of T-cell activation and proliferation in tumor microenvironment (Sica et al., 2006; Qian and Pollard, 2010), as well as inducing the infiltration of Tregs (Ino et al., 2013; Shigeoka et al., 2013). Here, TGFB1 is linked to neoplasm.