STAT3 and neoplasm: With the use of GSVA algorithm, oncogenic and immune-associated processes such as EMT, angiogenesis, IFN-γ response, and pathways such as p53 and IL6-JAK-STAT3 signaling pathways were relatively activated in TIME cluster C. The distinctive features suggested by GSVA further confirm the coexistence of slight preexisting anticancer immunity and overwhelming immunosuppressing processes in the tumor bed.