However, the results from the previous study, in contrast to our findings, indicate that PSME2 was down-regulated in gastric adenocarcinoma tissues compared to paired normal tissues and regulated GC progression by modulating the expression of chloride intracellular channel 1 (Huang et al., 2010; Zheng et al., 2012). This evidence concerns the gene CLIC1 and gastric adenocarcinoma.