Applications of OA imaging in the clinical research have shown promising results mainly in the peripheral with endogenous contrast (melanin, Hb, and HbO) such as in inflammatory bowl, dermatology, and breast cancer (Garcia-Uribe et al., 2015; Knieling et al., 2017; Masthoff et al., 2018; Nyayapathi et al., 2021). The gene discussed is GSTM1; the disease is breast cancer.