To screen for the crucial survival-related factors, the DEGs from the CD8+ T cells of HPV+ HNSCC were analyzed using single-variate Cox regression for the TCGA dataset, and a total of 21 DEGs were identified to be significantly correlated to survival in these patients (p < 0.05) (Figure 3B). The gene discussed is CD8A; the disease is head and neck squamous cell carcinoma.