When we used two SNPs (rs72711366 and rs77454118) to proxy the CpG site of cg2607605 (with AHRR expression), the effect of methylation on the risk of ER+ breast cancer achieved a nominal significance but did not pass the multiple testing threshold (OR = 1.05, 95% CI [1.02–1.08], p = 1.04E-03, q = 5.95E-02). The gene discussed is ESR1; the disease is breast cancer.