Furthermore, increasing evidence indicates the existence of a strong relationship between the aberrant rRNA synthesis and the development of cancers: on the one hand, altered rRNA processing may reduce the stability of the p53 gene, causing p53 to lose its tumor suppressor function; on the other hand, abnormal ribosomal biosynthesis causes altered translation and may result in increased translation of oncogenes and impaired translation of tumor suppressor genes (33). This evidence concerns the gene TP53 and cancer.