FURIN and COVID-19: Most recent studies unravel that multiple structural and non-structural specifics of SARS-CoV-2, such as unique FURIN cleavage site, papain-like protease (SCoV2-PLpro), ORF3b and nonstructural proteins, and dynamic conformational changes in the structure of spike protein during host cell fusion, which give it an edge in infectivity and virulence over previous coronaviruses causing pandemics. COVID-19 affects different people in different ways. The most common symptoms are fever, dry cough, shortness of breath, chills, sore throat, headache, or chest pain.