T2DM: Type 2 diabetes mellitus; SGLT2i: Sodium-glucose cotransporter-2 inhibitors; HF: Heart failure; CKD 3A: Chronic kidney disease stage 3A; UTI: Urinary tract infection; DKA: Diabetic ketoacidosis; eGFR: Estimated glomerular filtration rate. The gene discussed is SLC5A2; the disease is heart failure.