In this research, our findings first pointed out that the miRNA-101-3p expression level was significantly decreased in the IDD tissue and upregulation of the miRNA-101-3p could alleviate the IDD process by the STC1/VEGF/MAPK pathway, providing a novel IDD pathogenetic mechanism (Figure 5(c)). This evidence concerns the gene STC1 and intervertebral disk degenerative disorder.