CFAP46 and anxiety disorder: The stress environmental factors like early life adversity would trigger the DNA methylation change (Provençal and Binder, 2015), and epigenome-wide association study (EWAS) have reported many genes that showed epigenetic changes in anxiety disorders, including CFAP46 (Ziegler et al., 2019), SLC43A2, and TNXB (Wiegand et al., 2021).