TMPRSS2 and Familial prostate cancer: The current research shows that most of these 13 genes are closely related to the occurrence and development of tumors, like the TMPRSS2 gene, which is abnormally expressed in approximately 50% of cases of prostate cancer and is a key driver of prostate oncogenesis (Hong et al., 2020); COL23A1 plays an oncogenic role in clear cell renal cell carcinoma (Xu et al., 2017), and LINC01224 is also closely related to hepatocellular carcinoma and ovarian cancer (Gong et al., 2020; Xing et al., 2020).