Bioinformatics analysis found that the top two pathways of CEP55 involved in CRC were “mitotic nuclear division” and “cytokinetic process,” and the expression of CEP55 was positively correlated with immune infiltration of B cells, CD8+ T cells, neutrophils and dendritic cells which play an important role in the chronic Fn infection. Here, CEP55 is linked to colorectal carcinoma.