FN1 and malignant colon neoplasm: Recent studies indicated that Fn can bind to TLR4 with its lipopolysaccharide and activate the cascade reaction of p-pak-1/P-β-Catenins-675/c-myc/Cyclin-D1 to promote the malignant proliferation of colon cancer cells (Chen et al., 2017; Yang et al., 2017).