ST3GAL3 and cognition: Yoo et al. (2015) assessed neuroanatomy, brain histology, biochemistry as well as behavior in St3gal2 and St3gal3 single and double-null mutant mice. Notably, the authors demonstrated that sialylation of sialoglycoproteins is decreased approximately 50% in St3gal3–/– mice. Moreover, the authors reported alterations in different markers linked to oligodendrogenesis and the process of myelination (MBP, Olig2, and MAG). Additionally, they reported reduced motor coordination, marked cognitive deficits and hyperactive behavior in St3gal3 single-null mice.