Previous studies have documented global hypomethylation of CD4 T-cells in systemic lupus erythematosus, and systemic sclerosis (90, 91); it remains to be established whether these mechanisms are operative also in CD4 T cell subsets in AIH, possibly impacting AhR function and its ability to regulate downstream genes like CD39. The gene discussed is CD4; the disease is systemic lupus erythematosus.