When evaluating sex-specific direction of infection within couples (comparison 2, Figure 2 middle and lower panels), COVID-19[+] men and COVID-19[-] women, the strongest association is for two missense mutations in HLA-A, and this association is not detected when controlling for sex (Figure 2 upper panel) or when testing for other directions (Figure 2 lower panel). The gene discussed is HLA-A; the disease is infection.