Within non-permissive (antifungal) phagocytes (female Ly6c- monocyte-like macrophages), the top 5 canonical (active) metabolic pathways that were identified included Netrin Signaling (p=3.3E-03), Neuroprotective Role of THOP1 in Alzheimer’s Disease (p=4.31E-03), MIF-mediated Glycocorticoid Regulation (p=6.50E-03), Retinoate Biosynthesis I (p=6.50E-03), and the Apelin Muscle Signaling Pathway (p=8.02E-03) as shown in Table 3 and Figure 7B. This evidence concerns the gene APLN and early-onset autosomal dominant Alzheimer disease.