In the studies of animal infection models, RSV-infected TLR3-/- mice demonstrated significant elevated mucus production in the airways, which is associated with an increased expression of gob5 (a putative calcium-activated chloride channel thought to regulate mucus production and/or secretion), while depletion of IL-13 reduces gob5 expression in TLR3-/- mice (40). Here, CLCA1 is linked to infection.