Several studies have shown that CRC with Fusobacteria-high induced a series of specific tumor molecular events, including CIMP, MSI, and genetic mutations in KRAS, BRAF, TP53, etc. (Tahara et al., 2014; Mima et al., 2015, 2016; Yamaoka et al., 2018). The gene discussed is BRAF; the disease is colorectal carcinoma.