In fact, studies have concluded that endocrine imbalance in PCOS populations, including FSH deficiency, hypersecretion of LH, and hyperandrogenemia, hyperinsulinemia have adverse effects on oocyte maturation, fertilization rates and embryo quality, consequently resulting in impaired pregnancy rates, and increased pregnancy loss (38, 41–43). The gene discussed is PLOD1; the disease is Hyperinsulinemia.