Also, because of the increased acetylated FOXO3a level and decreased Bim expression, SIRT2 knockout mice showed resistance against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which induces neurotoxicity like Parkinson’s Disease (Liu et al., 2014). This evidence concerns the gene SIRT2 and Parkinson disease.