ADAM17 and colorectal carcinoma: Furthermore, exosomal ADAM17 levels were significantly increased in metastatic CRC cell lines (SW620 and Lovo) relative to those in SW480, DLD-1, HCT 116, and human colonic epithelial cells (HCoEpiC), as determined via western blot analysis (Figures 1E,F,H; Supplementary Figure S1B).