Combining the protein function in tumorigenesis and development, ADAM17 emerged as a prominent exosomal protein in liver metastasis-derived exosomes, with a low expression in exosomes from patients without metastasis and from healthy donors, suggestive of its specific association with CRC liver metastasis potential (Figures 1A–D; Supplementary Figure S1A). This evidence concerns the gene ADAM17 and colorectal carcinoma.