We found the following with XST injections: 1) enlarged LV structures; 2) increased clearance/removal of Aβ from LVs and lymph nodes and reduced amyloid plaque size and density in the brain (Huang et al., 2018; Mesquita et al., 2018); 3) higher level of anti-inflammatory cytokines (IL-1β and IL-10) and lower level of proinflammatory cytokine (IL-6) in both serum and brain; 4) an initial higher activation of microglia and astrocytes followed by reduced activation over the subsequent weeks to month. Here, IL1B is linked to amyloidosis.