AKT1 and neoplasm: This receptor superfamily includes GPCRs as classical chemoattractant receptors, inducing intracellular calcium mobilization, and activating MAPK/ERK, PI3K/Akt, and p38/MAPK signal transduction pathways (Snapkov et al., 2016) that modulate tumor cell proliferation and control cell migration and metastasis, regulate angiogenesis, and inhibit the immune cell infiltration into the tumor mass (Ambrosini and Aloisi, 2004).