PRNP and early-onset autosomal dominant Alzheimer disease: A familiar amyloidogenic protein associated with an FPR2 agonist is amyloid-β 1-42 (Aβ1-42), a well-documented peptide fragment in patients with Alzheimer’s disease (AD) (Wickstead et al., 2020), and the prion protein fragment PrP (106-126), which interacts with FPRs on astrocytes and microglia and regulates inflammatory process such as calcium mobilization, chemotaxis, and the production of pro-inflammatory cytokines (Le et al., 2001b).