On the contrary, decreased expression of Sfrp2, a physiological antagonist of Wnt signalling, promotes HCC progression (38); a reduction in Socs3 expression, a marker of JAK-STAT signalling is related to an increased risk of cancer development (39); and, finally, lower levels of Cdh1-coded protein, E-cadherin, will facilitate the tissue-infiltration and metastasis of cancer cells (40). This evidence concerns the gene SOCS3 and cancer.