Our previous study has shown that PCK1 depletion increases global O-GlcNAcylation levels through oxaloacetate accumulation, de novo UTP synthesis and AMPK-GFAT1 axis inactivation promoting uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis in hepatoma cells [16]. Here, PCK1 is linked to hepatocellular carcinoma.