In the J-HOP study of hypertensive patients, patients with higher NT-proBNP levels had a higher incidence of left ventricular hypertrophy or left ventricular space enlargement versus those with lower NT-proBNP levels, suggesting that high NT-proBNP levels may be indicative of organ damage due to elevated nocturnal BP [20]. The gene discussed is NPPB; the disease is left ventricular hypertrophy.