Familial hypercholesterolemia (FH) is a genetic disorder of LDL-C metabolism, mainly caused by mutations in the genes encoding the LDL receptor (LDLR), apolipoprotein B100 (APOB) or proprotein convertase subtilisin/kexin type 9 (PCSK9). The gene discussed is PCSK9; the disease is familial hyperaldosteronism.