For instance, using a mouse breast cancer model, it is shown that inhibition of mesenchymal phenotype by NEDD9-depletion significantly (by \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\approx$$\end{document}≈ 50%) reduces the number of circulating tumor cells. This evidence concerns the gene NEDD9 and neoplasm.