One recent study showed that upregulation DLEU1 is associated with increased levels of H3K4me3 and H3K27ac at its promoter region in multiple cancer cell lines, and DLEU1 also upregulates its neighboring gene SRP4 (KPNA3) by increasing H3K27ac at the SRP4 locus22. The gene discussed is KPNA3; the disease is cancer.