We found that all six subtypes of immune infiltration cells were associated with elevated PSMB8 expression in the following tissues: kidney renal papillary cell carcinoma (KIRP), brain lower grade glioma (LGG), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), sarcoma (SARC), skin cutaneous melanoma (SKCM), stomach adenocarcinoma (STAD), and testicular Germ Cell Tumors (TGCT). This evidence concerns the gene PSMB8 and cutaneous melanoma.