The results showed that 13 genes expression including 10 up-regulated genes (XAF1, IFI27, OAS1, OAS2, IFIT2, RSAD2, BST2, CCL20, NMU, CXCL5, Fig. 3A) and 3 down-regulated genes (C5, ADCY1, GNG7, Fig. 3B) were associated with significantly poorer overall survival in patients with PAAD, whereas 5 genes including 3 up-regulated genes (IRF4, IFI6 and CXCL3) and 2 down-regulated genes (CXCL12, LPAR3) showed no significant correlations19. The gene discussed is LPAR3; the disease is pancreatic adenocarcinoma.