However, the FMT from HV suppressed IBD/D+-F (UC/D+-F and CD/D+-F)-induced anxiety- and depression-like behaviors, NF-κB+/Iba1+, LPS+/Iba1+, and IL-1R+ cell populations, hippocampal IL-1β and IL-6 expression in the hippocampus, blood corticosterone, IL-6, and LPS levels, and colonic myeloperoxidase and IL-6 expression in mice, while the IBD/D+-F (UC/D+-F and CD/D+-F)-suppressed BDNF+/NeuN+ cell population increased in the hippocampus. This evidence concerns the gene IL1R1 and major depressive disorder.