However, the FMT from HV suppressed IBD/D+-F (UC/D+-F and CD/D+-F)-induced anxiety-like behaviors in the EPM, MB, and LDT tasks and depression-like behaviors in the TST and FST; and reduced the NF-κB+/Iba1+, LPS+/Iba1+, and IL-1R+ cell populations and IL-1β and IL-6 expression in the hippocampus and corticosterone, IL-6, and LPS levels in the blood, while the IBD/D+-F (UC/D+-F and CD/D+-F)-suppressed BDNF+/NeuN+ cell population increased. Here, IL1R1 is linked to major depressive disorder.