ESR1 and cancer: Figure 2 shows images for a 52-year-old woman with TN breast cancer, where Fig. 2a was grey-scale US images presenting with an irregular shape mass suspicious for cancer; Fig. 2b was pathological images with HE*400; Fig. 2c,d and 2e showed the absence of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2.