Additionally, TCGA data showed that CPNE7 expression in primary tumours was significantly upregulated compared to that in normal tissues in Cervical squamous cell carcinoma (CESC) and Head and Neck squamous cell carcinoma (HNSC) (p ≤ 0.05) (Fig. 2D) and could promote nodal metastasis (Fig. 2E). The gene discussed is CPNE7; the disease is head and neck squamous cell carcinoma.