To prove the clinical significance of our observation, we performed an immunofluorescence study with normal adjacent tissues and tumors derived from NSCLC and HCC patients, indicating that the percentage of pericyte-HK2 positive blood vessels was significantly up-regulated in tumors as compared to normal adjacent tissues (Fig. 4j and Supplementary fig. 5d). The gene discussed is HK2; the disease is hepatocellular carcinoma.