Indeed, we showed that treatment with HK2 inhibitor 3-bromopyruvate alone showed modest effect on subcutaneous lung or liver tumor growth, while co-administration of HK2 inhibitor and doxorubicin significantly inhibited the growth of the tumors by inducing MLC2-driven vasculature remodeling, while reducing tumor hypoxia without affecting tumor blood vessel density and pericyte coverage. This evidence concerns the gene HK2 and neoplasm.