Interestingly, treatment with 3-BP and doxorubicin showed no synergistic inhibitory effect on LLC cell growth in vitro, while exposure of NPC with conditioned medium from 3-BP or/and doxorubicin pre-treated tumor cells could still up-regulate HK2 and ROCK2 expression as compared with untreated NPC. This evidence concerns the gene HK2 and neoplasm.