HK2 and hepatocellular carcinoma: We next performed triple immunostaining of PDGFRβ, CD34, and α-SMA with our own NSCLC and HCC patient cohorts, indicating that high percentage of pericyte-HK2 positive blood vessels (i.e. when more than the mean number of tumor blood vessels are pericyte-HK2 positive blood vessels across individual patient samples in our NSCLC and HCC cohorts respectively) was associated with poor overall survival in NSCLC and HCC patients respectively (Fig. 4k and Supplementary fig. 5e).