Both RT-PCR and western blot analysis indicated that the conditioned medium of 3-BP or/and DOX pre-treated tumor cells could still up-regulate HK2 and ROCK2 expression in NSCLC/HCC-derived NPC as compared to untreated NPC group (Supplementary fig. 9a–e). The gene discussed is HK2; the disease is non-small cell lung carcinoma.