Strikingly, exposure with the conditioned medium (CM) from cancer cells did not affect the glucose uptake in NSCLC/HCC-derived NPC (Supplementary fig. 6t), while it increased the expression of HK2, ROCK2, and p-MLC2 as well as lactate production in NPC as compared with untreated NPC (Fig. 5p and Supplementary fig. 6u). This evidence concerns the gene HK2 and hepatocellular carcinoma.