Additionally, the role of pericyte-HK2 in regulating MLC-2-driven tumor vasculature remodeling and drug delivery was further illustrated by the co-injection experiments, showing that depletion of pericyte-HK2 expression also enhanced blood vessel perfusion and lumen diameter, which in turn increased chemotherapeutic drug delivery and efficacy against tumor growth, while overexpression of ROCK2 in HK2-depleted TPC reduced the enhanced blood vessel functions and drug delivery and efficacy against tumor growth observed in the mice that were co-injected with HK2-depleted TPC and cancer cells. The gene discussed is ROCK2; the disease is cancer.