HK2 and neoplasm: Interestingly, the tumor blood vessel diameter, basement membrane collagen IV staining, blood vessel perfusion, and intratumoral Hoechst were all increased in mice that were co-injected with A549 cells and HK2-depleted TPC as compared to mice co-injected with A549 cells and scramble transfected TPC, while the increased blood vessel functions observed were reduced in mice that were co-injected with A549 cells and ROCK2 overexpressing HK2-depleted TPC (Supplementary fig. 10l–o).