Importantly, ex vivo two photon imaging showed that the tumor blood vessel perfusion, vascular diameter, and doxorubicin delivery were all increased in the mice that were co-injected with A549 cells and HK2-depleted TPC as compared with the mice that were co-injected with A549 cells and scramble transfected TPC, while the increased blood vessel perfusion, vascular diameter, and doxorubicin delivery observed was decreased in mice that were co-injected with A549 cells and ROCK2 overexpressing HK2-depleted TPC (Supplementary fig. 10q and Supplementary movie 3–5). Here, HK2 is linked to neoplasm.