Strikingly, administration of doxorubicin reduced tumor growth in the mice that were co-injected with A549/MHCC-LM9 cells and HK2-depleted cells as compared to the mice that were co-injected with A549/MHCC-LM9 cells and scramble transfected TPC (Supplementary fig. 10a–h), while co-injection of A549/MHCC-LM9 cells with ROCK2 overexpressing HK2-depleted pericytes reduced the enhanced doxorubicin efficacy against tumor growth observed in mice co-injected with A549/MHCC-LM9 cells and HK2-depleted cells (Supplementary fig. 10a–h). This evidence concerns the gene ROCK2 and neoplasm.