The emerging biological mechanisms linking obesity to cancer initiation include alterations in adipokine pathophysiology [28], abnormalities in the IGF-I axis and insulin resistance [29, 30], metabolic reprogramming caused by lipid uptake [31], the existence of subclinical chronic low-grade inflammation and oxidative stress [32], and changes in the local immune microenvironment [8, 33]. This evidence concerns the gene IGF1 and cancer.