EGFR inhibitors, such as EKI-785, EKB-569, and Tesevatinib, and the Src inhibitor SKI-606, which also inhibits the EGFR signaling, have been shown to slow cyst growth in rodent models of ARPKD, ADPKD, and other forms of PKD [7, 9–11, 13]. The gene discussed is SRC; the disease is autosomal dominant polycystic kidney disease.