Two core signatures were immune-related: the first being a set of 47 genes, including APOE and C1Q{A,B,C} highly expressed by macrophages (Mø), suggesting that clusters in the corresponding supergroup might contain tumor-associated Mø16; the second was a set of 55 genes with lymphocyte and MHC class I–II-associated members (e.g., TRBC1, HLA-{A,B}, HLA-D{QB1,RA,RB1})44. The gene discussed is APOE; the disease is neoplasm.