Misfolding and aggregation of proteins and peptides into amyloidogenic fibrils are hallmarks of a wide range of neurodegenerative disorders1–3, including α-synuclein (αS) in Parkinson’s disease, the Aβ-peptide in Alzheimer’s disease, and Huntingtin (HTT) in Huntington’s disease4. The gene discussed is HTT; the disease is early-onset autosomal dominant Alzheimer disease.