RNF26 and acute promyelocytic leukemia: Besides, RNF26 expression has been reported to upregulated ubiquitously in several human cancer cell lines, including human promyelocytic leukemia (HL-60) cells, human cervical cancer (HeLa S3) cells, and human gastric cancer (MKN7) cells, and gastric cancer tissues, which implies that RNF26 might have the same cancer-related function in other tissues and cancers [11].