Moreover, DSPP mutation was associated with an increased IFN-γ signature gene expression in both our cohort (average score: 0.12 vs 0.08, P = 0.182; Supplementary Fig. S6a) and TCGA NSCLC cohort (average score: 0.49 vs 0.30, P < 0.001; Supplementary Fig. S6b). This evidence concerns the gene IFNG and non-small cell lung carcinoma.