TLR4 and schizophrenia: In light of conflicting reports regarding increased [11] and comparatively decreased [12] cortical TLR4 transcript levels in some patients, we posit that: (1) changes in TLR4 expression and microglial activation states in schizophrenia may be dynamic, and (2) neglecting to consider the neuroinflammatory status of individuals at their time of death when analysing immune-related transcripts in the brain may obscure the differences occurring in only a subset of patients.