NFKB1 and schizophrenia: RelB has been described as an ‘outlier’ in the NF-κB subunit family due to its several apparent anti-inflammatory roles (in addition to its dimer-forming, pro-inflammatory role) both in the nucleus and the cytoplasm [125], meaning less cortical RelB expression in people with schizophrenia could represent an additional failure to negatively regulate NF-κB.