These included myelin basic protein, Mbp (n = 112 junctions in cerebellum, n = 17 junctions in mature mTEC, FDR = 4.066 × 10−15), which is a target of autoantibodies in multiple sclerosis (Berger et al. 2003), and Cyp21a1 (n = 140 junctions in adrenal tissue, n = 5 junctions in mature mTEC, FDR = 1.76 × 10−21) the homolog of the human CYP21A2 gene that encodes cytochrome P450 family 21 subfamily A member 2 (also known as P450c21B), a major target of autoantibodies in Addison's disease (Winqvist et al. 1992). This evidence concerns the gene MBP and primary adrenal insufficiency.