BRCA2 and prostate cancer: Men with cancer-predisposing BRCA2 variants like Rahul have an increased risk of prostate cancer: a recent meta-analysis indicated an odds ratio of 2.64(17), and a large prospective cohort study in the UK and Ireland found a 27% absolute risk of developing prostate cancer by age 75, rising to 60% by age 85(10) (for comparison, population risk by age 85 is 16% in England and Wales based on Office for National Statistics 2016 data).