Inhibition of both GAPDH and HK-2 by 3BP has been shown in several studies; however, a recent study by Jardim-Messeder et al. [48] demonstrated that a 1-h treatment with 100 μM 3BP did not suppress HK-2 activity in hepatocellular carcinoma cells (HepG2), as the data presented here also suggest. This evidence concerns the gene GAPDH and hepatocellular carcinoma.