VEGF-A-signalling through VEGFR-2 leads to the protection of dorsal root ganglion sensory neurons in models of drug (paclitaxel) or hyperglycaemia-induced neuropathies, through induction of Heat Shock Protein 90 deacetylation and increase of Bcl-2 [9, 10]. Here, VEGFA is linked to Hyperglycemia.